# Introduction

Spatial domains refer to regions on tissue sections that exhibit specific gene expression patterns. These regions are usually spatially continuous and display a certain degree of functional consistency. By identifying spatial domains, researchers can better understand how cells within a tissue interact with each other and how they work together to perform complex biological processes, and provides a classification basis for [differential gene analysis](https://mysite.gitbook.io/sdas_manual_eng/readme/04_manual/deg) .

## Reference

* Long, Y., Ang, K. S., Li, M., Chong, K. L. K., Sethi, R., Zhong, C., ... & Chen, J. (2023). Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST. *Nature Communications*, *14*(1), 1155.