Introduction

This module is based on pyscenic analysis of cell-gene expression matrices to predict interactions between transcription factors (TFs) and target genes. Combined with transcription factor activity heatmaps, specificity expression plots, etc., it explores the role of transcription factor regulatory networks in cell subpopulations and constructs intracellular gene regulatory maps.

Reference

• Van de Sande, B., Flerin, C., Davie, K., De Waegeneer, M., Hulselmans, G., Aibar, S., ... & Aerts, S. (2020). A scalable SCENIC workflow for single-cell gene regulatory network analysis. Nature protocols, 15(7), 2247-2276.